Homo sapiens Gene: ADCY1
Summary
InnateDB Gene IDBG-15668.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY1
Gene Name adenylate cyclase 1 (brain)
Synonyms AC1; DFNB44;
Species Homo sapiens
Ensembl Gene ENSG00000164742
Encoded Proteins
adenylate cyclase 1 (brain)
adenylate cyclase 1 (brain)
adenylate cyclase 1 (brain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain. [provided by RefSeq, Jul 2008]
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45574140-45723116
Strand Forward strand
Band p12.3
Transcripts
ENST00000297323 ENSP00000297323
ENST00000432715 ENSP00000392721
ENST00000468353
ENST00000621543 ENSP00000479770
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004016 adenylate cyclase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006171 cAMP biosynthetic process
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007409 axonogenesis
GO:0007616 long-term memory
GO:0007623 circadian rhythm
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0010226 response to lithium ion
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0042752 regulation of circadian rhythm
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by FGFR in disease pathway
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
Adenylate cyclase activating pathway pathway
CaM pathway pathway
Signalling by NGF pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PKA-mediated phosphorylation of CREB pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Phospholipase C-mediated cascade pathway
Adenylate cyclase inhibitory pathway pathway
DAP12 signaling pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
Neuronal System pathway
Signaling by EGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
PLC beta mediated events pathway
GABA receptor activation pathway
Glucagon signaling in metabolic regulation pathway
PLC-gamma1 signalling pathway
Opioid Signalling pathway
Activation of GABAB receptors pathway
DAG and IP3 signaling pathway
PKA activation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Hedgehog 'off' state pathway
Post NMDA receptor activation events pathway
G-protein mediated events pathway
Immune System pathway
Downstream signal transduction pathway
G alpha (z) signalling events pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
GABA B receptor activation pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Signaling by FGFR pathway
Signaling by PDGF pathway
PKA activation in glucagon signalling pathway
Signaling by ERBB2 pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inhibition of adenylate cyclase pathway pathway
PLCG1 events in ERBB2 signaling pathway
Ca-dependent events pathway
Calmodulin induced events pathway
Aquaporin-mediated transport pathway
Disease pathway
DAP12 interactions pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
Purine metabolism pathway
Calcium signaling pathway pathway
Chemokine signaling pathway pathway
Oocyte meiosis pathway
Vascular smooth muscle contraction pathway
Gap junction pathway
Long-term potentiation pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Bile secretion pathway
Chagas disease (American trypanosomiasis) pathway
Amoebiasis pathway
Dilated cardiomyopathy pathway
INOH
GPCR signaling pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
Regulation of spermatogenesis by crem [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
Chrebp regulation by carbohydrates and camp [Biocarta view]
How progesterone initiates the oocyte maturation [Biocarta view]
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
Activation of camp-dependent protein kinase pka [Biocarta view]
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL C9J1J0
UniProt Splice Variant
Entrez Gene 107
UniGene Hs.192215
RefSeq NM_001281768 NM_021116 XM_005249584 XM_005249585
HUGO HGNC:232
OMIM 103072
CCDS CCDS75593 CCDS34631
HPRD 00053
IMGT
EMBL AC069008 AC091439 CH471128
GenPept EAW61047
RNA Seq Atlas 107