Homo sapiens Gene: STK11
InnateDB Gene IDBG-13950.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STK11
Gene Name serine/threonine kinase 11
Synonyms hLKB1; LKB1; PJS
Species Homo sapiens
Ensembl Gene ENSG00000118046
Encoded Proteins
serine/threonine kinase 11
serine/threonine kinase 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1177558-1228435
Strand Forward strand
Band p13.3
ENST00000326873 ENSP00000324856
ENST00000585851 ENSP00000467912
ENST00000593219 ENSP00000466610
ENST00000585748 ENSP00000477641
ENST00000586243 ENSP00000467240
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 71 [view]
Protein-Protein 69 [view]
Protein-DNA 2 [view]
Protein-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030275 LRR domain binding
GO:0030295 protein kinase activator activity
GO:0032403 protein complex binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001894 tissue homeostasis
GO:0001944 vasculature development
GO:0006112 energy reserve metabolic process
GO:0006468 protein phosphorylation
GO:0006914 autophagy
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007286 spermatid development
GO:0007409 axonogenesis
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010212 response to ionizing radiation
GO:0030010 establishment of cell polarity
GO:0030111 regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147 activation of protein kinase activity
GO:0033762 response to glucagon
GO:0033993 response to lipid
GO:0036399 TCR signalosome assembly
GO:0042304 regulation of fatty acid biosynthetic process
GO:0042593 glucose homeostasis
GO:0043276 anoikis
GO:0043434 response to peptide hormone
GO:0044281 small molecule metabolic process
GO:0045059 positive thymic T cell selection
GO:0045722 positive regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050772 positive regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051291 protein heterooligomerization
GO:0051645 Golgi localization
GO:0051896 regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0036398 TCR signalosome
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
EGFR1 pathway
TGF_beta_Receptor pathway
Regulation of AMPK activity via LKB1 pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
AMPK inhibits chREBP transcriptional activation activity pathway
Integration of energy metabolism pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
PKB-mediated events pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Metabolism pathway
mTOR signaling pathway pathway
Adipocytokine signaling pathway pathway
LKB1 signaling events
SwissProt Q15831
UniProt Splice Variant
Entrez Gene 6794
UniGene Hs.515005
RefSeq NM_000455 XM_005259617
OMIM 602216
HPRD 03740
EMBL AC004221 AC011544 AF032984 AF035625 AF055320 AF055321 AF055322 AF055323 AF055324 AF055325 AF055326 AF055327 AK314858 BC007981 BC019334 CH471139 U63333
GenPept AAB05809 AAB97833 AAC15742 AAC39527 AAF97257 AAH07981 AAH19334 BAG37374 EAW69540
RNA Seq Atlas 6794