Version 5.4
Homo sapiens Gene: STK11
Summary
InnateDB Gene IDBG-13950.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STK11
Gene Name serine/threonine kinase 11
Synonyms hLKB1; LKB1; PJS
Species Homo sapiens
Ensembl Gene ENSG00000118046
Encoded Proteins
IDBP-13952
serine/threonine kinase 11
IDBP-760068
IDBP-763094
IDBP-812799
serine/threonine kinase 11
IDBP-764896
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1177558-1228435
Strand Forward strand
Band p13.3
Transcripts
ENST00000326873 ENSP00000324856
ENST00000589152
ENST00000585465
ENST00000585851 ENSP00000467912
ENST00000593219 ENSP00000466610
ENST00000591133
ENST00000585748 ENSP00000477641
ENST00000586243 ENSP00000467240
ENST00000586358
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 71 [view]
Protein-Protein 69 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030275 LRR domain binding
GO:0030295 protein kinase activator activity
GO:0032403 protein complex binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001894 tissue homeostasis
GO:0001944 vasculature development
GO:0006112 energy reserve metabolic process
GO:0006468 protein phosphorylation
GO:0006914 autophagy
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007286 spermatid development
GO:0007409 axonogenesis
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010212 response to ionizing radiation
GO:0030010 establishment of cell polarity
GO:0030111 regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147 activation of protein kinase activity
GO:0033762 response to glucagon
GO:0033993 response to lipid
GO:0036399 TCR signalosome assembly
GO:0042304 regulation of fatty acid biosynthetic process
GO:0042593 glucose homeostasis
GO:0043276 anoikis
GO:0043434 response to peptide hormone
GO:0044281 small molecule metabolic process
GO:0045059 positive thymic T cell selection
GO:0045722 positive regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050772 positive regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051291 protein heterooligomerization
GO:0051645 Golgi localization
GO:0051896 regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0036398 TCR signalosome
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003068
View Gene Order
ENSBTAG00000011639
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_21285
Regulation of AMPK activity via LKB1 pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_1988
AMPK inhibits chREBP transcriptional activation activity pathway
REACT_1505
Integration of energy metabolism pathway
REACT_21387
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_456
PKB-mediated events pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_111217
Metabolism pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
Cross-References
SwissProt Q15831
TrEMBL Q9NS52
UniProt Splice Variant
Entrez Gene 6794
UniGene Hs.515005
RefSeq NM_000455 XM_005259617
HUGO HGNC:11389
OMIM 602216
CCDS CCDS45896
HPRD 03740
IMGT
EMBL AC004221 AC011544 AF032984 AF035625 AF055320 AF055321 AF055322 AF055323 AF055324 AF055325 AF055326 AF055327 AK314858 BC007981 BC019334 CH471139 U63333
GenPept AAB05809 AAB97833 AAC15742 AAC39527 AAF97257 AAH07981 AAH19334 BAG37374 EAW69540
RNA Seq Atlas 6794

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca