Homo sapiens Gene: PPL
Summary
InnateDB Gene IDBG-13291.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPL
Gene Name periplakin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118898
Encoded Proteins
periplakin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4882507-4960741
Strand Reverse strand
Band p13.3
Transcripts
ENST00000345988 ENSP00000340510
ENST00000592772 ENSP00000467699
ENST00000588556
ENST00000590782 ENSP00000465640
ENST00000589090
ENST00000590093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0031424 keratinization
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030057 desmosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.192233
RefSeq NM_002705 XM_006720902
HUGO
OMIM
CCDS CCDS10526
HPRD 04187
IMGT
EMBL
GenPept
RNA Seq Atlas