|Homo sapiens Gene: PPL|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Useful resources||Stemformatics EHFPI ImmGen|
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 16:4882507-4960741|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Possible paralog/unusual divergence/ gene prediction error
|UniProt Splice Variant|
|RNA Seq Atlas|