Version 5.4
Homo sapiens Protein: PPL
Summary
InnateDB Protein IDBP-13293.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPL
Protein Name periplakin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340510
InnateDB Gene IDBG-13291 (PPL)
Protein Structure
UniProt Annotation
Function Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269PubMed:9412476}.
Subcellular Localization Cell junction, desmosome {ECO:0000269PubMed:9412476}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9412476}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Associated with desmosomes and intermediate filaments.
Disease Associations
Tissue Specificity Expressed in stratified squamous epithelia and in some other epithelia. {ECO:0000269PubMed:9412476, ECO:0000269PubMed:9521878}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0031424 keratinization
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030057 desmosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001101 Plectin repeat
IPR018159 Spectrin/alpha-actinin
PFAM PF00681
PRINTS
PIRSF
SMART SM00250
SM00150
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60437
PhosphoSite PhosphoSite-O60437
TrEMBL
UniProt Splice Variant
Entrez Gene 5493
UniGene Hs.192233
RefSeq NP_002696
HUGO HGNC:9273
OMIM 602871
CCDS CCDS10526
HPRD 04187
IMGT
EMBL AB011140 AC027687 AF001691 AF013717 AF040999 AF041000 AF041002 AF041003 AF041004 BC114620 CH471112
GenPept AAC17738 AAC39668 AAD17459 AAI14621 BAA25494 EAW85248

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca