Homo sapiens Gene: GTSE1
Summary
InnateDB Gene IDBG-11949.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTSE1
Gene Name G-2 and S-phase expressed 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000075218
Encoded Proteins
G-2 and S-phase expressed 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:46296741-46330810
Strand Forward strand
Band q13.31
Transcripts
ENST00000454366 ENSP00000415430
ENST00000479645
ENST00000466510
ENST00000491863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000085 mitotic G2 phase
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007017 microtubule-based process
Cellular Component
GO:0005881 cytoplasmic microtubule
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
p53 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NYZ3
TrEMBL
UniProt Splice Variant
Entrez Gene 51512
UniGene Hs.386189 Hs.607318 Hs.630739
RefSeq NM_016426 XM_005261627
HUGO HGNC:13698
OMIM 607477
CCDS CCDS14074
HPRD 09593
IMGT
EMBL AF223408 AK222806 AK315550 AL031588 BC006325 BC075828 CT841519 Z93024
GenPept AAF31459 AAH06325 AAH75828 BAD96526 BAG37928 CAJ86449 CAQ09324 CAQ10552
RNA Seq Atlas 51512