Version 5.4
Homo sapiens Protein: GTSE1
Summary
InnateDB Protein IDBP-380167.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTSE1
Protein Name G-2 and S-phase expressed 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000415430
InnateDB Gene IDBG-11949 (GTSE1)
Protein Structure
UniProt Annotation
Function May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.
Subcellular Localization Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000085 mitotic G2 phase
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007017 microtubule-based process
Cellular Component
GO:0005881 cytoplasmic microtubule
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NYZ3
PhosphoSite PhosphoSite-Q9NYZ3
TrEMBL
UniProt Splice Variant
Entrez Gene 51512
UniGene Hs.630739
RefSeq NP_057510
HUGO HGNC:13698
OMIM 607477
CCDS CCDS14074
HPRD 09593
IMGT
EMBL AF223408 AK222806 AK315550 AL031588 BC006325 BC075828 CT841519 Z93024
GenPept AAF31459 AAH06325 AAH75828 BAD96526 BAG37928 CAJ86449 CAQ09324 CAQ10552

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca