Version 5.4
Homo sapiens Gene: SPPL2A
Summary
InnateDB Gene IDBG-11868.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPPL2A
Gene Name signal peptide peptidase like 2A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138600
Encoded Proteins
IDBP-11870
Signal peptide peptidase-like 2A
IDBP-600115
Signal peptide peptidase-like 2A
IDBP-586388
Signal peptide peptidase-like 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:50702266-50765808
Strand Reverse strand
Band q21.2
Transcripts
ENST00000261854 ENSP00000261854
ENST00000558934 ENSP00000453927
ENST00000559293
ENST00000558146
ENST00000559527
ENST00000558414 ENSP00000453932
ENST00000560288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0031293 membrane protein intracellular domain proteolysis
GO:0050776 regulation of immune response
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0031902 late endosome membrane
GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027366
View Gene Order
ENSBTAG00000011831
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.401537
RefSeq NM_032802
HUGO
OMIM
CCDS CCDS10138
HPRD 09742
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca