InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPPL2A

Summary

InnateDB Protein

IDBP-11870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPPL2A

Protein Name

Signal peptide peptidase-like 2A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261854

InnateDB Gene

IDBG-11868 (SPPL2A)

Protein Structure

UniProt Annotation

Function

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. {ECO:0000269PubMed:16829951, ECO:0000269PubMed:16829952, ECO:0000269PubMed:17557115, ECO:0000269PubMed:17965014}.

Subcellular Localization

Late endosome membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269PubMed:16829952}. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:15385547}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0031293	membrane protein intracellular domain proteolysis
GO:0050776	regulation of immune response

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030660	Golgi-associated vesicle membrane
GO:0031902	late endosome membrane
GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane