Version 5.4
Homo sapiens Gene: IRX2
Summary
InnateDB Gene IDBG-11371.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRX2
Gene Name iroquois homeobox 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170561
Encoded Proteins
IDBP-11373
iroquois homeobox 2
IDBP-11375
iroquois homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:2745845-2751662
Strand Reverse strand
Band p15.33
Transcripts
ENST00000382611 ENSP00000372056
ENST00000302057 ENSP00000307006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001656 metanephros development
GO:0006355 regulation of transcription, DNA-templated
GO:0072086 specification of loop of Henle identity
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000001504
View Gene Order
Cross-References
SwissProt Q9BZI1
TrEMBL
UniProt Splice Variant
Entrez Gene 153572
UniGene Hs.282089 Hs.608078
RefSeq NM_001134222 NM_033267
HUGO HGNC:14359
OMIM 606198
CCDS CCDS3868
HPRD
IMGT
EMBL AB188492 AF319967 AY335939 AY335940 BC065189
GenPept AAH65189 AAK01202 AAQ16545 AAQ16546 BAD37140
RNA Seq Atlas 153572

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca