Version 5.4
Homo sapiens Protein: IRX2
Summary
InnateDB Protein IDBP-11373.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRX2
Protein Name iroquois homeobox 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000372056
InnateDB Gene IDBG-11371 (IRX2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001656 metanephros development
GO:0006355 regulation of transcription, DNA-templated
GO:0072086 specification of loop of Henle identity
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR003893 Iroquois-class homeodomain protein
IPR009057 Homeodomain-like
PFAM PF00046
PRINTS
PIRSF
SMART SM00389
SM00548
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZI1
PhosphoSite PhosphoSite-Q9BZI1
TrEMBL
UniProt Splice Variant
Entrez Gene 153572
UniGene Hs.608078
RefSeq NP_001127694
HUGO HGNC:14359
OMIM 606198
CCDS CCDS3868
HPRD 09368
IMGT
EMBL AB188492 AF319967 AY335939 AY335940 BC065189
GenPept AAH65189 AAK01202 AAQ16545 AAQ16546 BAD37140

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca