Homo sapiens Gene: CREB5
Summary
InnateDB Gene IDBG-10759.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREB5
Gene Name cAMP responsive element binding protein 5
Synonyms CRE-BPA;
Species Homo sapiens
Ensembl Gene ENSG00000146592
Encoded Proteins
cAMP responsive element binding protein 5
cAMP responsive element binding protein 5
cAMP responsive element binding protein 5
cAMP responsive element binding protein 5
cAMP responsive element binding protein 5
cAMP responsive element binding protein 5
cAMP responsive element binding protein 5
cAMP responsive element binding protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:28299321-28825894
Strand Forward strand
Band p15.1
Transcripts
ENST00000357727 ENSP00000350359
ENST00000396300 ENSP00000379594
ENST00000396299 ENSP00000379593
ENST00000396298 ENSP00000379592
ENST00000409603 ENSP00000387197
ENST00000424599 ENSP00000394088
ENST00000426500 ENSP00000394979
ENST00000469531
ENST00000478078
ENST00000482692
ENST00000461921
ENST00000468391
ENST00000484383
ENST00000468813
ENST00000498316 ENSP00000440429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0045444 fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060612 adipose tissue development
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Vasopressin-regulated water reabsorption pathway
Huntington's disease pathway
Prostate cancer pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q02930
TrEMBL C9JN33
UniProt Splice Variant
Entrez Gene 9586
UniGene Hs.437075 Hs.607561
RefSeq NM_182899 NM_182898 NM_004904 NM_001011666 XM_005249906
HUGO HGNC:16844
OMIM
CCDS CCDS43562 CCDS5417 CCDS5418 CCDS43563
HPRD 09896
IMGT
EMBL AB451409 AC003074 AC005013 AC005105 AC006331 AC006367 AC006980 AK292916 AK300455 AK316187 BC059400 CH471073 L05515 L05911 L05912 L05913
GenPept AAA52072 AAC37525 AAC37526 AAC37527 AAH59400 AAP22329 AAS00387 BAF85605 BAG62175 BAG70223 BAH14558 EAW93908 EAW93910
RNA Seq Atlas 9586