InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CREB5

Summary

InnateDB Gene

IDBG-10759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREB5

Gene Name

cAMP responsive element binding protein 5

Synonyms

CRE-BPA

Species

Homo sapiens

Ensembl Gene

ENSG00000146592

Encoded Proteins

IDBP-10761

cAMP responsive element binding protein 5

IDBP-237813

cAMP responsive element binding protein 5

IDBP-237815

cAMP responsive element binding protein 5

IDBP-237817

cAMP responsive element binding protein 5

IDBP-294610

cAMP responsive element binding protein 5

IDBP-369736

cAMP responsive element binding protein 5

IDBP-369752

cAMP responsive element binding protein 5

IDBP-599507

cAMP responsive element binding protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:28299321-28825894

Strand

Forward strand

Band

p15.1

Transcripts

ENST00000357727	ENSP00000350359
ENST00000396300	ENSP00000379594
ENST00000396299	ENSP00000379593
ENST00000396298	ENSP00000379592
ENST00000409603	ENSP00000387197
ENST00000424599	ENSP00000394088
ENST00000426500	ENSP00000394979
ENST00000469531
ENST00000478078
ENST00000482692
ENST00000461921
ENST00000468391
ENST00000484383
ENST00000468813
ENST00000498316	ENSP00000440429

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0045444	fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060612	adipose tissue development

Cellular Component

GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000053007

View Gene Order

ENSBTAG00000018909

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05215

Prostate cancer pathway

hsa05016

Huntington's disease pathway

hsa04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.437075 Hs.607561

RefSeq

NM_001011666 NM_004904 NM_182898 NM_182899 XM_005249906

HUGO

OMIM

CCDS

CCDS43562 CCDS43563 CCDS5417 CCDS5418

HPRD

09896

IMGT

EMBL

GenPept

RNA Seq Atlas