Homo sapiens Gene: ZFP36L1
Summary
InnateDB Gene IDBG-10189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFP36L1
Gene Name zinc finger protein 36, C3H type-like 1
Synonyms Berg36; BRF1; cMG1; ERF-1; ERF1; RNF162B; TIS11B;
Species Homo sapiens
Ensembl Gene ENSG00000185650
Encoded Proteins
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:68787660-68796253
Strand Reverse strand
Band q24.1
Transcripts
ENST00000336440 ENSP00000337386
ENST00000439696 ENSP00000388402
ENST00000555997 ENSP00000451093
ENST00000557086 ENSP00000450784
ENST00000557022 ENSP00000450600
ENST00000553375 ENSP00000452119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0001570 vasculogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006417 regulation of translation
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0033077 T cell differentiation in thymus
GO:0043488 regulation of mRNA stability
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt Q07352
TrEMBL A0A024R658 B4DG15 B4E1N3 G3V2D5
UniProt Splice Variant
Entrez Gene 677
UniGene Hs.605465 Hs.655774 Hs.707091 Hs.732674 Hs.734777 Hs.85155
RefSeq NM_001244698 NM_001244701 NM_004926
HUGO HGNC:1107
OMIM 601064
CCDS CCDS9791
HPRD 03041
IMGT
EMBL AK294363 AK303917 AL132986 BC018340 BT019468 CH471061 X79066 X79067 X99404
GenPept AAH18340 AAV38275 BAG57626 BAG64845 CAA55670 CAA67781 EAW80967 EAW80968
RNA Seq Atlas 677