InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zfp36l1

Summary

InnateDB Gene

IDBG-153355.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp36l1

Gene Name

zinc finger protein 36, C3H type-like 1

Synonyms

AW742437; AW743212; Berg36; Brf1; cMG1; D530020L18Rik; ERF1; TIS11b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021127

Encoded Proteins

IDBP-153357

zinc finger protein 36, C3H type-like 1

IDBP-620936

zinc finger protein 36, C3H type-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185650:
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:80107760-80113013

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021552	ENSMUSP00000021552
ENSMUST00000165114	ENSMUSP00000127522

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0001570	vasculogenesis
GO:0006402	mRNA catabolic process
GO:0006417	regulation of translation
GO:0033077	T cell differentiation in thymus
GO:0043488	regulation of mRNA stability

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000185650

View Gene Order

ENSBTAG00000025434

Not yet available

Pathways

NETPATH

REACTOME

REACT_198687

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_198695

Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway

REACT_233572

Gene Expression pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_24915

Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

Cross-References

SwissProt

P23950

TrEMBL

Q543H2

UniProt Splice Variant

Entrez Gene

12192

UniGene

Mm.235132 Mm.436162

RefSeq

NM_007564

OMIM

CCDS

CCDS26010

HPRD

IMGT

MGI ID

MGI:107946

MGI Symbol

Zfp36l1

EMBL

AK036950 AK051035 CH466590 M58566

GenPept

AAA72948 BAC29648 BAC34506 EDL02654

RNA Seq Atlas

12192