InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MLXIPL

Summary

InnateDB Gene

IDBG-640050.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLXIPL

Gene Name

carbohydrate-responsive element-binding protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009153

Encoded Proteins

IDBP-692262

MLX interacting protein-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000009950:
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:34125794-34143852

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012060

ENSBTAP00000012060

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0010255	glucose mediated signaling pathway
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042593	glucose homeostasis
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045821	positive regulation of glycolytic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046889	positive regulation of lipid biosynthetic process
GO:0071157	negative regulation of cell cycle arrest
GO:0090324	negative regulation of oxidative phosphorylation