Mus musculus Gene: Mlxipl
Summary
InnateDB Gene IDBG-203540.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mlxipl
Gene Name MLX interacting protein-like
Synonyms bHLHd14; ChREBP; Wbscr14; WS-bHLH
Species Mus musculus
Ensembl Gene ENSMUSG00000005373
Encoded Proteins
MLX interacting protein-like
MLX interacting protein-like
MLX interacting protein-like
MLX interacting protein-like
MLX interacting protein-like
MLX interacting protein-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000009950:
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:135106891-135138382
Strand Forward strand
Band G2
Transcripts
ENSMUST00000005507 ENSMUSP00000005507
ENSMUST00000141770
ENSMUST00000142385
ENSMUST00000153519 ENSMUSP00000122198
ENSMUST00000128691 ENSMUSP00000121348
ENSMUST00000129008 ENSMUSP00000114933
ENSMUST00000154840 ENSMUSP00000121668
ENSMUST00000123370 ENSMUSP00000116358
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0035538 carbohydrate response element binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0010255 glucose mediated signaling pathway
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0042593 glucose homeostasis
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046889 positive regulation of lipid biosynthetic process
GO:0055089 fatty acid homeostasis
GO:0071157 negative regulation of cell cycle arrest
GO:0090324 negative regulation of oxidative phosphorylation
GO:2000505 regulation of energy homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Metabolism pathway
PP2A-mediated dephosphorylation of key metabolic factors pathway
ChREBP activates metabolic gene expression pathway
AMPK inhibits chREBP transcriptional activation activity pathway
PKA-mediated phosphorylation of key metabolic factors pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
PP2A-mediated dephosphorylation of key metabolic factors pathway
ChREBP activates metabolic gene expression pathway
PKA-mediated phosphorylation of key metabolic factors pathway
AMPK inhibits chREBP transcriptional activation activity pathway
Integration of energy metabolism pathway
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q99MZ3
TrEMBL
UniProt Splice Variant
Entrez Gene 58805
UniGene Mm.34213
RefSeq NM_021455 XM_006504481 XM_006504483 XM_006504485
OMIM
CCDS CCDS39316
HPRD
IMGT
MGI ID MGI:1927999
MGI Symbol Mlxipl
EMBL AF156604 AF245475 AF245476 AF245477 AF245478 AF245479
GenPept AAF68175 AAK20940 AAK20941 AAK20942 AAK20943 AAK20944
RNA Seq Atlas 58805