InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mlxipl

Summary

InnateDB Gene

IDBG-203540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mlxipl

Gene Name

MLX interacting protein-like

Synonyms

bHLHd14; ChREBP; Wbscr14; WS-bHLH

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005373

Encoded Proteins

IDBP-203542

MLX interacting protein-like

IDBP-540683

MLX interacting protein-like

IDBP-534024

MLX interacting protein-like

IDBP-539776

MLX interacting protein-like

IDBP-532483

MLX interacting protein-like

IDBP-540559

MLX interacting protein-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000009950:
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:135106891-135138382

Strand

Forward strand

Band

Transcripts

ENSMUST00000005507	ENSMUSP00000005507
ENSMUST00000141770
ENSMUST00000142385
ENSMUST00000153519	ENSMUSP00000122198
ENSMUST00000128691	ENSMUSP00000121348
ENSMUST00000129008	ENSMUSP00000114933
ENSMUST00000154840	ENSMUSP00000121668
ENSMUST00000123370	ENSMUSP00000116358

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035538	carbohydrate response element binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0010255	glucose mediated signaling pathway
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042593	glucose homeostasis
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045821	positive regulation of glycolytic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046889	positive regulation of lipid biosynthetic process
GO:0055089	fatty acid homeostasis
GO:0071157	negative regulation of cell cycle arrest
GO:0090324	negative regulation of oxidative phosphorylation
GO:2000505	regulation of energy homeostasis