Version 5.4
Mus musculus Gene: Fkbp14
Summary
InnateDB Gene IDBG-149031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fkbp14
Gene Name FK506 binding protein 14
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038074
Encoded Proteins
IDBP-149033
FK506 binding protein 14
IDBP-401252
FK506 binding protein 14
IDBP-533957
FK506 binding protein 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106080:
The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:54577604-54597344
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000046520 ENSMUSP00000046070
ENSMUST00000117375 ENSMUSP00000112526
ENSMUST00000155047 ENSMUSP00000114521
ENSMUST00000133446
ENSMUST00000123832
ENSMUST00000141757
ENSMUST00000143312
ENSMUST00000154907
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005509 calcium ion binding
GO:0005528 FK506 binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0018208 peptidyl-proline modification
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000106080
View Gene Order
ENSBTAG00000007870
Not yet available
Pathways
NETPATH
REACTOME
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_247926
Metabolism of proteins pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.274693 Mm.408224 Mm.418596
RefSeq NM_153573
OMIM
CCDS CCDS20157
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca