Version 5.4
Homo sapiens Gene: ERN2
Summary
InnateDB Gene IDBG-20788.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERN2
Gene Name endoplasmic reticulum to nucleus signaling 2
Synonyms IRE1-BETA; IRE1b
Species Homo sapiens
Ensembl Gene ENSG00000134398
Encoded Proteins
IDBP-20790
endoplasmic reticulum to nucleus signaling 2
IDBP-372937
endoplasmic reticulum to nucleus signaling 2
IDBP-754524
IDBP-747370
IDBP-748803
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:23690326-23713500
Strand Reverse strand
Band p12.2
Transcripts
ENST00000256797 ENSP00000256797
ENST00000457008 ENSP00000413812
ENST00000569903 ENSP00000457796
ENST00000566565
ENST00000562458 ENSP00000456866
ENST00000562562 ENSP00000457361
ENST00000561478
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004519 endonuclease activity
GO:0004540 ribonuclease activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0007050 cell cycle arrest
GO:0016075 rRNA catabolic process
GO:0030263 apoptotic chromosome condensation
GO:0034976 response to endoplasmic reticulum stress
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030866
View Gene Order
ENSBTAG00000014456
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10595
UniGene Hs.592041
RefSeq NM_033266 XM_005255044
HUGO HGNC:16942
OMIM 604034
CCDS CCDS32407
HPRD 04944
IMGT
EMBL
GenPept
RNA Seq Atlas 10595

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca