InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERN2

Summary

InnateDB Protein

IDBP-20790.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERN2

Protein Name

endoplasmic reticulum to nucleus signaling 2

Synonyms

IRE1-BETA; IRE1b;

Species

Homo sapiens

Ensembl Protein

ENSP00000256797

InnateDB Gene

IDBG-20788 (ERN2)

Protein Structure

UniProt Annotation

Function

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269PubMed:11175748}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:11175748}; Single-pass type I membrane protein {ECO:0000269PubMed:11175748}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004519	endonuclease activity
GO:0004540	ribonuclease activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0007050	cell cycle arrest
GO:0016075	rRNA catabolic process
GO:0030263	apoptotic chromosome condensation
GO:0034976	response to endoplasmic reticulum stress
GO:0045892	negative regulation of transcription, DNA-templated
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090501	RNA phosphodiester bond hydrolysis

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR006567 PUG domain
IPR010513 KEN domain
IPR011009 Protein kinase-like domain
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06479

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00580
SM00564
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt