Version 5.4
Mus musculus Gene: Ern2
Summary
InnateDB Gene IDBG-208930.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ern2
Gene Name endoplasmic reticulum (ER) to nucleus signalling 2
Synonyms Ern1; Ire1; Ire1b
Species Mus musculus
Ensembl Gene ENSMUSG00000030866
Encoded Proteins
IDBP-208932
endoplasmic reticulum (ER) to nucleus signalling 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134398:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:122169893-122186216
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000033153 ENSMUSP00000033153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004519 endonuclease activity
GO:0004540 ribonuclease activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007050 cell cycle arrest
GO:0016075 rRNA catabolic process
GO:0030263 apoptotic chromosome condensation
GO:0034976 response to endoplasmic reticulum stress
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134398
View Gene Order
ENSBTAG00000014456
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.20452
RefSeq NM_012016 XM_006507882 XM_006507883
OMIM
CCDS CCDS21813
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca