InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERN2

Summary

InnateDB Protein

IDBP-372937.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERN2

Protein Name

endoplasmic reticulum to nucleus signaling 2

Synonyms

IRE1-BETA; IRE1b;

Species

Homo sapiens

Ensembl Protein

ENSP00000413812

InnateDB Gene

IDBG-20788 (ERN2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004540	ribonuclease activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0090501	RNA phosphodiester bond hydrolysis

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR006567 PUG domain
IPR010513 KEN domain
IPR011009 Protein kinase-like domain
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06479

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00580
SM00564
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt