InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BID

Summary

InnateDB Gene

IDBG-1050.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BID

Gene Name

BH3 interacting domain death agonist

Synonyms

FP497

Species

Homo sapiens

Ensembl Gene

ENSG00000015475

Encoded Proteins

IDBP-1052

BH3 interacting domain death agonist

IDBP-1058

BH3 interacting domain death agonist

IDBP-229813

BH3 interacting domain death agonist

IDBP-229815

BH3 interacting domain death agonist

IDBP-229817

BH3 interacting domain death agonist

IDBP-596970

BH3 interacting domain death agonist

IDBP-812719

BH3 interacting domain death agonist

IDBP-812720

BH3 interacting domain death agonist

IDBP-812721

BH3 interacting domain death agonist

IDBP-812722

BH3 interacting domain death agonist

IDBP-812724

BH3 interacting domain death agonist

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21552281

BID is a critical component of the NOD signalling pathway and is crucial for the peptidoglycan inflammation response. BID deficient mice are unresponsive to local or systemic exposure to NOD agonist or their protective effects in experimental colitis. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21552281

[Mus musculus] Bid is a critical component of the NOD signalling pathway and is crucial for the peptidoglycan inflammation response. Bid deficient mice are unresponsive to local or systemic exposure to NOD agonist or their protective effects in experimental colitis.

Entrez Gene

Summary

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:17734138-17774770

Strand

Reverse strand

Band

q11.21

Transcripts

ENST00000317361	ENSP00000318822
ENST00000342111	ENSP00000344594
ENST00000399774	ENSP00000382674
ENST00000399767	ENSP00000382669
ENST00000399765	ENSP00000382667
ENST00000494097
ENST00000473439
ENST00000550946
ENST00000551952	ENSP00000449236
ENST00000552886
ENST00000622694	ENSP00000480414
ENST00000611040	ENSP00000483709
ENST00000615414	ENSP00000483534
ENST00000614949	ENSP00000477773
ENST00000617586	ENSP00000481991

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	99 [view]
Protein-Protein	97 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005123	death receptor binding
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006626	protein targeting to mitochondrion
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007420	brain development
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008637	apoptotic mitochondrial changes
GO:0032355	response to estradiol
GO:0032459	regulation of protein oligomerization
GO:0032461	positive regulation of protein oligomerization
GO:0032464	positive regulation of protein homooligomerization
GO:0034349	glial cell apoptotic process
GO:0042127	regulation of cell proliferation
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051260	protein homooligomerization
GO:0051402	neuron apoptotic process
GO:0090150	establishment of protein localization to membrane
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:2000045	regulation of G1/S transition of mitotic cell cycle
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0032592	integral component of mitochondrial membrane
GO:0070062	extracellular vesicular exosome