InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BID

Summary

InnateDB Protein

IDBP-229815.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BID

Protein Name

BH3 interacting domain death agonist

Synonyms

FP497;

Species

Homo sapiens

Ensembl Protein

ENSP00000382669

InnateDB Gene

IDBG-1050 (BID)

Protein Structure

UniProt Annotation

Function

The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250, ECO:0000269PubMed:14583606}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion membrane {ECO:0000250}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269PubMed:14583606}.BH3-interacting domain death agonist p15: Mitochondrion membrane {ECO:0000250}. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250}.BH3-interacting domain death agonist p13: Mitochondrion membrane {ECO:0000250}. Note=Associated with the mitochondrial membrane. {ECO:0000250}.Isoform 1: Cytoplasm.Isoform 3: Cytoplasm.Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.

Disease Associations

Tissue Specificity

Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). {ECO:0000269PubMed:14583606}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	99 [view]
Protein-Protein	97 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005123	death receptor binding
GO:0005515	protein binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006915	apoptotic process
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008637	apoptotic mitochondrial changes
GO:0032461	positive regulation of protein oligomerization
GO:0032464	positive regulation of protein homooligomerization
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051402	neuron apoptotic process
GO:0090150	establishment of protein localization to membrane
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome