InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BID

Summary

InnateDB Gene

IDBG-641320.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BID

Gene Name

BH3-interacting domain death agonist

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013988

Encoded Proteins

IDBP-693668

BH3 interacting domain death agonist

IDBP-693669

BH3 interacting domain death agonist

IDBP-693673

BH3 interacting domain death agonist

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21552281

[Homo sapiens] BID is a critical component of the NOD signalling pathway and is crucial for the peptidoglycan inflammation response. BID deficient mice are unresponsive to local or systemic exposure to NOD agonist or their protective effects in experimental colitis. (Demonstrated in murine model)

PMID 21552281

[Mus musculus] Bid is a critical component of the NOD signalling pathway and is crucial for the peptidoglycan inflammation response. Bid deficient mice are unresponsive to local or systemic exposure to NOD agonist or their protective effects in experimental colitis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000015475:
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:109639251-109656755

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000042737	ENSBTAP00000040367
ENSBTAT00000018590	ENSBTAP00000018590
ENSBTAT00000055486	ENSBTAP00000048685

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006626	protein targeting to mitochondrion
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008637	apoptotic mitochondrial changes
GO:0032459	regulation of protein oligomerization
GO:0032461	positive regulation of protein oligomerization
GO:0032464	positive regulation of protein homooligomerization
GO:0042127	regulation of cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0051260	protein homooligomerization
GO:0090150	establishment of protein localization to membrane
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097191	extrinsic apoptotic signaling pathway
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:2000045	regulation of G1/S transition of mitotic cell cycle
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane
GO:0032592	integral component of mitochondrial membrane
GO:0070062	extracellular vesicular exosome