InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bid

Summary

InnateDB Gene

IDBG-184076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bid

Gene Name

BH3 interacting domain death agonist

Synonyms

2700049M22Rik; AI875481; AU022477

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004446

Encoded Proteins

IDBP-184078

BH3 interacting domain death agonist

IDBP-534869

BH3 interacting domain death agonist

IDBP-540652

BH3 interacting domain death agonist

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21552281

Bid is a critical component of the NOD signalling pathway and is crucial for the peptidoglycan inflammation response. Bid deficient mice are unresponsive to local or systemic exposure to NOD agonist or their protective effects in experimental colitis.

InnateDB Annotation from Orthologs

Summary

PMID 21552281

[Homo sapiens] BID is a critical component of the NOD signalling pathway and is crucial for the peptidoglycan inflammation response. BID deficient mice are unresponsive to local or systemic exposure to NOD agonist or their protective effects in experimental colitis. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000015475:
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:120891930-120916853

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004560	ENSMUSP00000004560
ENSMUST00000160684	ENSMUSP00000125731
ENSMUST00000161594
ENSMUST00000145948	ENSMUSP00000117529
ENSMUST00000125915

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006626	protein targeting to mitochondrion
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007420	brain development
GO:0008637	apoptotic mitochondrial changes
GO:0032355	response to estradiol
GO:0032459	regulation of protein oligomerization
GO:0032461	positive regulation of protein oligomerization
GO:0032464	positive regulation of protein homooligomerization
GO:0034349	glial cell apoptotic process
GO:0042127	regulation of cell proliferation
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051260	protein homooligomerization
GO:0090150	establishment of protein localization to membrane
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097191	extrinsic apoptotic signaling pathway
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:2000045	regulation of G1/S transition of mitotic cell cycle
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane
GO:0032592	integral component of mitochondrial membrane
GO:0070062	extracellular vesicular exosome