InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCHR1

Summary

InnateDB Protein

IDBP-8831.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCHR1

Protein Name

melanin-concentrating hormone receptor 1

Synonyms

GPR24; MCH-1R; MCH1R; SLC-1; SLC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000249016

InnateDB Gene

IDBG-8827 (MCHR1)

Protein Structure

UniProt Annotation

Function

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. {ECO:0000269PubMed:10421367}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008022	protein C-terminus binding
GO:0008188	neuropeptide receptor activity
GO:0030273	melanin-concentrating hormone receptor activity
GO:0042562	hormone binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007631	feeding behavior
GO:0051928	positive regulation of calcium ion transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031513	nonmotile primary cilium

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR004047 Melanin-concentrating hormone 1 receptor
IPR008361 Melanin-concentrating hormone receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01507
PR01783

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99705