InnateDB Protein
|
IDBP-8807.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CRMP1
|
Protein Name
|
collapsin response mediator protein 1
|
Synonyms
|
CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000321606
|
InnateDB Gene
|
IDBG-8805 (CRMP1)
|
Protein Structure
|
|
Function |
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. {ECO:0000269PubMed:11562390, ECO:0000269PubMed:19799413}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11562390}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:11562390}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:11562390}. Note=Associated with centrosomes and the mitotic spindle during metaphase.
|
Disease Associations |
|
Tissue Specificity |
Brain.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
105
[view]
|
Protein-Protein |
104
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005515
|
protein binding
|
GO:0016787
|
hydrolase activity
|
GO:0016810
|
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
|
GO:0016812
|
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR006680
Amidohydrolase 1
IPR011059
Metal-dependent hydrolase, composite domain
IPR011778
Hydantoinase/dihydropyrimidinase
|
PFAM |
PF01979
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q14194
|
PhosphoSite |
PhosphoSite-Q14194
|
TrEMBL |
X5DNI1
|
UniProt Splice Variant |
|
Entrez Gene |
1400
|
UniGene |
Hs.739348
|
RefSeq |
NP_001275591
|
HUGO |
HGNC:2365
|
OMIM |
602462
|
CCDS |
CCDS33950
|
HPRD |
03913
|
IMGT |
|
EMBL |
AC105915
AH010780
AK094725
BC000252
BC007613
BC007898
BT006806
CH471131
D78012
DQ206871
KJ534816
U17278
|
GenPept |
AAA93201
AAH00252
AAH07613
AAH07898
AAK55500
AAP35452
AAY40959
ABB22046
AHW56456
BAA11190
BAG52919
EAW82405
EAW82406
EAW82407
|
|
|