InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TP53BP1

Summary

InnateDB Protein

IDBP-8464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP53BP1

Protein Name

tumor protein p53 binding protein 1

Synonyms

53BP1; p202;

Species

Homo sapiens

Ensembl Protein

ENSP00000263801

InnateDB Gene

IDBG-8462 (TP53BP1)

Protein Structure

UniProt Annotation

Function

Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation. {ECO:0000269PubMed:12364621, ECO:0000269PubMed:17190600, ECO:0000269PubMed:21144835}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.

Disease Associations

Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	162 [view]
Protein-Protein	160 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0035064	methylated histone binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006366	transcription from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity