InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATF4

Summary

InnateDB Protein

IDBP-8411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATF4

Protein Name

activating transcription factor 4 (tax-responsive enhancer element B67)

Synonyms

CREB-2; CREB2; TAXREB67; TXREB;

Species

Homo sapiens

Ensembl Protein

ENSP00000336790

InnateDB Gene

IDBG-8409 (ATF4)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000250, ECO:0000269PubMed:15775988, ECO:0000269PubMed:16682973, ECO:0000269PubMed:18940792}.

Subcellular Localization

Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	111 [view]
Protein-Protein	101 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006094	gluconeogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006520	cellular amino acid metabolic process
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032922	circadian regulation of gene expression
GO:0034976	response to endoplasmic reticulum stress
GO:0043267	negative regulation of potassium ion transport
GO:0043525	positive regulation of neuron apoptotic process
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0032590	dendrite membrane