InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C5

Summary

InnateDB Protein

IDBP-83169.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

complement component 5

Synonyms

C5a; C5b; C5D; CPAMD4; ECLZB;

Species

Homo sapiens

Ensembl Protein

ENSP00000223642

InnateDB Gene

IDBG-83167 (C5)

Protein Structure

UniProt Annotation

Function

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

Subcellular Localization

Secreted.

Disease Associations

Complement component 5 deficiency (C5D) [MIM:609536]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele. {ECO:0000269PubMed:15995705}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0031714	C5a anaphylatoxin chemotactic receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001701	in utero embryonic development
GO:0002523	leukocyte migration involved in inflammatory response
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006950	response to stress
GO:0006954	inflammatory response
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010700	negative regulation of norepinephrine secretion
GO:0010760	negative regulation of macrophage chemotaxis
GO:0010951	negative regulation of endopeptidase activity
GO:0019835	cytolysis
GO:0030449	regulation of complement activation
GO:0033602	negative regulation of dopamine secretion
GO:0042593	glucose homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0050921	positive regulation of chemotaxis
GO:0060326	cell chemotaxis
GO:0090197	positive regulation of chemokine secretion

Cellular Component

GO:0005576	extracellular region
GO:0005579	membrane attack complex
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000020 Anaphylatoxin/fibulin
IPR001134 Netrin domain
IPR001599 Alpha-2-macroglobulin
IPR001840 Anaphylatoxin, complement system domain
IPR002890 Alpha-2-macroglobulin, N-terminal
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 Alpha-macroglobulin complement component
IPR018081 Anaphylatoxin, complement system
IPR018933 Netrin module, non-TIMP type

PFAM