Version 5.4
Homo sapiens Protein: PRKD1
Summary
InnateDB Protein IDBP-811816.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKD1
Protein Name protein kinase D1
Synonyms PKC-MU; PKCM; PKD; PRKCM;
Species Homo sapiens
Ensembl Protein ENSP00000482645
InnateDB Gene IDBG-4215 (PRKD1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006468 protein phosphorylation
GO:0006665 sphingolipid metabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007030 Golgi organization
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0008283 cell proliferation
GO:0010595 positive regulation of endothelial cell migration
GO:0010837 regulation of keratinocyte proliferation
GO:0010976 positive regulation of neuron projection development
GO:0018105 peptidyl-serine phosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034599 cellular response to oxidative stress
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045806 negative regulation of endocytosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048193 Golgi vesicle transport
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060548 negative regulation of cell death
GO:1901727 positive regulation of histone deacetylase activity
GO:2001028 positive regulation of endothelial cell chemotaxis
GO:2001044 regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF00169
PF00130
PRINTS PR00109
PR00008
PIRSF
SMART SM00233
SM00109
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q1KKQ2
UniProt Splice Variant
Entrez Gene 5587
UniGene
RefSeq
HUGO HGNC:9407
OMIM 605435
CCDS
HPRD
IMGT
EMBL AK314170 AL135858 CH471078 DQ485452 X75756
GenPept ABE96833 BAG36853 CAA53384 EAW65971

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca