InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADD1

Summary

InnateDB Protein

IDBP-7703.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADD1

Protein Name

adducin 1 (alpha)

Synonyms

ADDA;

Species

Homo sapiens

Ensembl Protein

ENSP00000264758

InnateDB Gene

IDBG-7701 (ADD1)

Protein Structure

UniProt Annotation

Function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008134	transcription factor binding
GO:0030507	spectrin binding
GO:0042608	T cell receptor binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0006884	cell volume homeostasis
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0020027	hemoglobin metabolic process
GO:0030036	actin cytoskeleton organization
GO:0030218	erythrocyte differentiation
GO:0030837	negative regulation of actin filament polymerization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032092	positive regulation of protein binding
GO:0035264	multicellular organism growth
GO:0044267	cellular protein metabolic process
GO:0045766	positive regulation of angiogenesis
GO:0045807	positive regulation of endocytosis
GO:0048873	homeostasis of number of cells within a tissue
GO:0051016	barbed-end actin filament capping
GO:0051017	actin filament bundle assembly
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0008290	F-actin capping protein complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030425	dendrite
GO:0043197	dendritic spine
GO:0045111	intermediate filament cytoskeleton
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm