InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARPP19

Summary

InnateDB Protein

IDBP-745845.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARPP19

Protein Name

Synonyms

ARPP-16; ARPP-19; ARPP16; ENSAL;

Species

Homo sapiens

Ensembl Protein

ENSP00000454234

InnateDB Gene

IDBG-12735 (ARPP19)

Protein Structure

UniProt Annotation

Function

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269PubMed:21164014}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0005102	receptor binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0015459	potassium channel regulator activity
GO:0019212	phosphatase inhibitor activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0043086	negative regulation of catalytic activity
GO:0045722	positive regulation of gluconeogenesis
GO:0046326	positive regulation of glucose import
GO:0050790	regulation of catalytic activity