Version 5.4
Bos taurus Protein: RAD51
Summary
InnateDB Protein IDBP-699040.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD51
Protein Name DNA repair protein RAD51 homolog 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003788
InnateDB Gene IDBG-646257 (RAD51)
Protein Structure
UniProt Annotation
Function Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2- scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Predicted by orthology
Total 68 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0042802 identical protein binding
GO:0043142 single-stranded DNA-dependent ATPase activity
GO:0070182 DNA polymerase binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006268 DNA unwinding involved in DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007126 meiotic nuclear division
GO:0009432 SOS response
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0051106 positive regulation of DNA ligation
GO:0051260 protein homooligomerization
GO:0071479 cellular response to ionizing radiation
GO:0072757 cellular response to camptothecin
Cellular Component
GO:0000228 nuclear chromosome
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000800 lateral element
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0016605 PML body
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003593 AAA+ ATPase domain
IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
IPR011941 DNA recombination/repair protein Rad51
IPR013632 DNA recombination and repair protein Rad51, C-terminal
IPR013765 DNA recombination and repair protein RecA
IPR016467 DNA recombination and repair protein, RecA-like
IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF08423
PF00154
PRINTS PR00142
PIRSF PIRSF005856
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KJ94
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514749
UniGene Bt.36197
RefSeq NP_001039644
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105458
GenPept AAI05459

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca