InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.40228

Summary

InnateDB Protein

IDBP-698973.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.40228

Protein Name

RAS guanyl-releasing protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000029159

InnateDB Gene

IDBG-646190 (BT.40228)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0046872	metal ion binding

Biological Process

GO:0001816	cytokine production
GO:0002437	inflammatory response to antigenic stimulus
GO:0007264	small GTPase mediated signal transduction
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
GO:0032252	secretory granule localization
GO:0032856	activation of Ras GTPase activity
GO:0032862	activation of Rho GTPase activity
GO:0035556	intracellular signal transduction
GO:0043303	mast cell degranulation
GO:0047496	vesicle transport along microtubule
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0042629	mast cell granule

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00618
PF00617
PF00036
PF13202
PF13405
PF00130

PRINTS

PR00008

PIRSF

SMART

SM00229
SM00147
SM00054
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt