Version 5.4
Bos taurus Protein: DBNL
Summary
InnateDB Protein IDBP-696625.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DBNL
Protein Name Drebrin-like protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023325
InnateDB Gene IDBG-644017 (DBNL)
Protein Structure
UniProt Annotation
Function Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell projection {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0051015 actin filament binding
Biological Process
GO:0002376 immune system process
GO:0006810 transport
GO:0006897 endocytosis
GO:0007416 synapse assembly
GO:0016601 Rac protein signal transduction
GO:0048812 neuron projection morphogenesis
GO:0071800 podosome assembly
Cellular Component
GO:0000139 Golgi membrane
GO:0001726 ruffle
GO:0002102 podosome
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030665 clathrin-coated vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR002108 Actin-depolymerising factor homology domain
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF00241
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00102
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6H7G2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514706
UniGene Bt.13577
RefSeq NP_001092440
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146234 BT030669
GenPept AAI46235 ABS44985

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca