Version 5.4
Bos taurus Protein: FGFR3
Summary
InnateDB Protein IDBP-696506.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGFR3
Protein Name fibroblast growth factor receptor 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009427
InnateDB Gene IDBG-643902 (FGFR3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0001501 skeletal system development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002009 morphogenesis of an epithelium
GO:0002089 lens morphogenesis in camera-type eye
GO:0006468 protein phosphorylation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010518 positive regulation of phospholipase activity
GO:0014003 oligodendrocyte development
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021762 substantia nigra development
GO:0022010 central nervous system myelination
GO:0030154 cell differentiation
GO:0030900 forebrain development
GO:0031398 positive regulation of protein ubiquitination
GO:0035019 somatic stem cell maintenance
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410 positive regulation of MAPK cascade
GO:0043525 positive regulation of neuron apoptotic process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045597 positive regulation of cell differentiation
GO:0045839 negative regulation of mitosis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0046777 protein autophosphorylation
GO:0048546 digestive tract morphogenesis
GO:0048678 response to axon injury
GO:0048712 negative regulation of astrocyte differentiation
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051216 cartilage development
GO:0060113 inner ear receptor cell differentiation
GO:0060349 bone morphogenesis
GO:0060385 axonogenesis involved in innervation
GO:0061144 alveolar secondary septum development
GO:0070307 lens fiber cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072148 epithelial cell fate commitment
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0090102 cochlea development
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902178 fibroblast growth factor receptor apoptotic signaling pathway
Cellular Component
GO:0005764 lysosome
GO:0005887 integral component of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016248 Fibroblast growth factor receptor family
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF07679
PF00047
PRINTS PR00109
PIRSF PIRSF000628
SMART SM00220
SM00408
SM00409
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q95KL3
UniProt Splice Variant
Entrez Gene 281769
UniGene
RefSeq NP_776743
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY029187 DAAA02018569 DAAA02018570 DAAA02018571
GenPept AAK38171

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca