InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GRK4

Summary

InnateDB Protein

IDBP-696198.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRK4

Protein Name

G protein-coupled receptor kinase 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001970

InnateDB Gene

IDBG-643613 (GRK4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016310	phosphorylation
GO:0031623	receptor internalization
GO:0038032	termination of G-protein coupled receptor signaling pathway

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000239 GPCR kinase
IPR000342 Regulator of G protein signalling domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016137 Regulator of G protein signalling superfamily
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00615
PF00069
PF07714

PRINTS

PR00717
PR01301
PR00109

PIRSF

SMART

SM00133
SM00220
SM00315
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt