InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SULT1B1

Summary

InnateDB Protein

IDBP-695320.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT1B1

Protein Name

Sulfotransferase family cytosolic 1B member 1

Synonyms

ST1B1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001650

InnateDB Gene

IDBG-642827 (SULT1B1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004062	aryl sulfotransferase activity
GO:0008146	sulfotransferase activity
GO:0016740	transferase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0009812	flavonoid metabolic process
GO:0018958	phenol-containing compound metabolic process
GO:0030855	epithelial cell differentiation
GO:0042403	thyroid hormone metabolic process
GO:0051923	sulfation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00685

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3T0Y3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

521920

UniGene

Bt.13723

RefSeq

NP_001069291

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102208

GenPept

AAI02209