InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GPR77

Summary

InnateDB Protein

IDBP-692185.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR77

Protein Name

C5a anaphylatoxin chemotactic receptor C5L2

Synonyms

C5L2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000047680

InnateDB Gene

IDBG-639987 (GPR77)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004944	C5a anaphylatoxin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032720	negative regulation of tumor necrosis factor production
GO:0050679	positive regulation of epithelial cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090024	negative regulation of neutrophil chemotaxis
GO:1900165	negative regulation of interleukin-6 secretion
GO:2000482	regulation of interleukin-8 secretion

Cellular Component

GO:0009925	basal plasma membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001274 C5a1/C5a2 anaphylatoxin chemotactic receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00426

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q08DZ7

UniProt Splice Variant

Entrez Gene

522144

UniGene

Bt.45845

RefSeq

NP_001071415

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123493 DAAA02047415 EF030605

GenPept

AAI23494 ABI98946