Version 5.4
Bos taurus Protein: ITGA4
Summary
InnateDB Protein IDBP-692146.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA4
Protein Name integrin alpha-4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012194
InnateDB Gene IDBG-639925 (ITGA4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 394 interaction(s) predicted by orthology.
Predicted by orthology
Total 394 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001974 blood vessel remodeling
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007507 heart development
GO:0016477 cell migration
GO:0060324 face development
GO:0060710 chorio-allantoic fusion
GO:0072678 T cell migration
GO:0090074 negative regulation of protein homodimerization activity
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000413 Integrin alpha chain
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
PFAM PF01839
PF14312
PF08441
PRINTS PR01185
PIRSF
SMART SM00191
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MEF6
UniProt Splice Variant
Entrez Gene 282882
UniGene Bt.8130
RefSeq NP_777173
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02004077 DAAA02004078
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca