InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TLR7

Summary

InnateDB Protein

IDBP-691441.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLR7

Protein Name

toll-like receptor 7

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000029890

InnateDB Gene

IDBG-639302 (TLR7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0003727	single-stranded RNA binding
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0035197	siRNA binding

Biological Process

GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007252	I-kappaB phosphorylation
GO:0032722	positive regulation of chemokine production
GO:0032755	positive regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0034154	toll-like receptor 7 signaling pathway
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045356	positive regulation of interferon-alpha biosynthetic process
GO:0045359	positive regulation of interferon-beta biosynthetic process
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0051607	defense response to virus
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032009	early phagosome
GO:0043235	receptor complex