Version 5.4
Bos taurus Protein: BT.24055
Summary
InnateDB Protein IDBP-690943.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.24055
Protein Name complement C5a anaphylatoxin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016204
InnateDB Gene IDBG-638834 (BT.24055)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006954 inflammatory response
GO:0006956 complement activation
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010760 negative regulation of macrophage chemotaxis
GO:0010951 negative regulation of endopeptidase activity
GO:0045766 positive regulation of angiogenesis
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000020 Anaphylatoxin/fibulin
IPR001134 Netrin domain
IPR001599 Alpha-2-macroglobulin
IPR001840 Anaphylatoxin, complement system domain
IPR002890 Alpha-2-macroglobulin, N-terminal
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 Alpha-macroglobulin complement component
IPR018081 Anaphylatoxin, complement system
IPR018933 Netrin module, non-TIMP type
PFAM PF01821
PF00207
PF01835
PF07677
PF07703
PF07678
PF01759
PRINTS PR00004
PIRSF
SMART SM00104
SM00643
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q1A7A4
UniProt Splice Variant
Entrez Gene 512045
UniGene
RefSeq NP_001160088
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02024787 DAAA02024788 DAAA02024789 DAAA02024790 DQ282117
GenPept ABB89309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca