InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NF2

Summary

InnateDB Protein

IDBP-688169.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NF2

Protein Name

neurofibromin 2 (merlin)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017489

InnateDB Gene

IDBG-636202 (NF2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0001707	mesoderm formation
GO:0006469	negative regulation of protein kinase activity
GO:0007398	ectoderm development
GO:0007420	brain development
GO:0008156	negative regulation of DNA replication
GO:0008285	negative regulation of cell proliferation
GO:0014010	Schwann cell proliferation
GO:0021766	hippocampus development
GO:0022408	negative regulation of cell-cell adhesion
GO:0030036	actin cytoskeleton organization
GO:0031647	regulation of protein stability
GO:0035330	regulation of hippo signaling
GO:0042127	regulation of cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0043409	negative regulation of MAPK cascade
GO:0045216	cell-cell junction organization
GO:0045597	positive regulation of cell differentiation
GO:0046426	negative regulation of JAK-STAT cascade
GO:0051496	positive regulation of stress fiber assembly
GO:0070306	lens fiber cell differentiation
GO:1900180	regulation of protein localization to nucleus
GO:2000177	regulation of neural precursor cell proliferation

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0016020	membrane
GO:0019898	extrinsic component of membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030864	cortical actin cytoskeleton
GO:0032154	cleavage furrow
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000533 Tropomyosin
IPR000798 Ezrin/radixin/moesin like
IPR008954 Moesin tail domain
IPR011174 Ezrin/radixin/moesin
IPR011259 Ezrin/radixin/moesin, C-terminal
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF00261
PF12718
PF00769
PF09379
PF09380
PF00373

PRINTS

PR00194
PR00661
PR00935

PIRSF

PIRSF002305

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References