InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LOXL2

Summary

InnateDB Protein

IDBP-686887.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LOXL2

Protein Name

lysyl oxidase homolog 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008159

InnateDB Gene

IDBG-635071 (LOXL2)

Protein Structure

UniProt Annotation

Function

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associated with chromatin (By similarity). It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0004720	protein-lysine 6-oxidase activity
GO:0005044	scavenger receptor activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0035064	methylated histone binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0001666	response to hypoxia
GO:0001837	epithelial to mesenchymal transition
GO:0001935	endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0006464	cellular protein modification process
GO:0006898	receptor-mediated endocytosis
GO:0016570	histone modification
GO:0018277	protein deamination
GO:0030199	collagen fibril organization
GO:0032332	positive regulation of chondrocyte differentiation
GO:0043542	endothelial cell migration
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046688	response to copper ion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR001695 Lysyl oxidase
IPR017448 SRCR-like domain

PFAM

PF00530
PF01186

PRINTS

PR00258
PR00074

PIRSF

SMART

SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

M0QVZ4

UniProt Splice Variant

Entrez Gene

532684

UniGene

RefSeq

NP_001092523

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC149766 DAAA02023574 DAAA02023575 DAAA02023576 DAAA02023577 DAAA02023578

GenPept

AAI49767