InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CHGA

Summary

InnateDB Protein

IDBP-685508.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHGA

Protein Name

chromogranin-A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012973

InnateDB Gene

IDBG-633773 (CHGA)

Protein Structure

UniProt Annotation

Function

Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.Chromostatin completely inhibits catecholamine release from chromaffin cells.Chromacin has antibacterial activity against M.luteus. Not active against E.coli.Catestatin inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non- competitive nicotinic cholinergic antagonist.Vasostatin-1 has antibacterial activity against Gram- positive bacteria M.luteus, B.megaterium. Not active against Gram- positive bacteria B.cereus, B.subtilis, S.pyogenes, M.fortuitum, S.aureus and L.monocytogenes and against Gram-negative bacteria E.coli, E.cloacae, S.typhimurium, K.pneumoniae and P.aeruginosa. Possesses antifungal activity against N.crassa, A.fumigatus, A.brassicicola, N.hematococca, F.culmorum and F.oxyporum and against the yeast S.cerevisiae and C.albicans. Inactive against T.mentagrophytes.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0016525	negative regulation of angiogenesis
GO:0030155	regulation of cell adhesion
GO:0031640	killing of cells of other organism
GO:0042742	defense response to bacterium
GO:0045087	innate immune response
GO:0046676	negative regulation of insulin secretion
GO:0046888	negative regulation of hormone secretion
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus

Cellular Component

GO:0005576	extracellular region
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030141	secretory granule
GO:0030658	transport vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0048471	perinuclear region of cytoplasm