InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DAP

Summary

InnateDB Protein

IDBP-683121.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAP

Protein Name

Death-associated protein 1

Synonyms

DAP-1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008327

InnateDB Gene

IDBG-631574 (DAP)

Protein Structure

UniProt Annotation

Function

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0070513	death domain binding

Biological Process

GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010507	negative regulation of autophagy
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0034198	cellular response to amino acid starvation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0097190	apoptotic signaling pathway

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5EAE6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

616066

UniGene

Bt.44425

RefSeq

NP_001071526

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103332 BT020623

GenPept

AAI03333 AAX08640