InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ZAP70

Summary

InnateDB Protein

IDBP-681269.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZAP70

Protein Name

zeta-chain (TCR) associated protein kinase 70kDa

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007743

InnateDB Gene

IDBG-629842 (ZAP70)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001784	phosphotyrosine binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035556	intracellular signal transduction
GO:0043366	beta selection
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0045061	thymic T cell selection
GO:0045582	positive regulation of T cell differentiation
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0046777	protein autophosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0042101	T cell receptor complex
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00017
PF14633
PF07714

PRINTS

PR00401
PR00109

PIRSF

PIRSF000604

SMART

SM00252
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References