InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grm7

Summary

InnateDB Protein

IDBP-624496.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm7

Protein Name

glutamate receptor, metabotropic 7

Synonyms

6330570A01Rik; BB176677; C030018L03; E130018M02Rik; Gpr1g; Gprc1g; mGluR7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133957

InnateDB Gene

IDBG-174797 (Grm7)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005245	voltage-gated calcium channel activity
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0008066	glutamate receptor activity
GO:0010855	adenylate cyclase inhibitor activity
GO:0016595	glutamate binding
GO:0030165	PDZ domain binding
GO:0070905	serine binding

Biological Process

GO:0001661	conditioned taste aversion
GO:0001662	behavioral fear response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007605	sensory perception of sound
GO:0007608	sensory perception of smell
GO:0007613	memory
GO:0007614	short-term memory
GO:0008306	associative learning
GO:0019226	transmission of nerve impulse
GO:0030534	adult behavior
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0031279	regulation of cyclase activity
GO:0033555	multicellular organismal response to stress
GO:0050877	neurological system process
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0070588	calcium ion transmembrane transport
GO:1901214	regulation of neuron death

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0043235	receptor complex
GO:0048787	presynaptic active zone membrane

Protein Structure and Domains

PDB ID

MGI:1351344

InterPro

IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000337 GPCR, family 3
IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
IPR001828 Extracellular ligand-binding receptor
IPR001883 GPCR, family 3, metabotropic glutamate receptor 7
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR00593
PR00248
PR01054
PR01057

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q68ED2