Version 5.4
Homo sapiens Protein: RIC8A
Summary
InnateDB Protein IDBP-603864.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIC8A
Protein Name resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000432008
InnateDB Gene IDBG-15573 (RIC8A)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. {ECO:0000250, ECO:0000269PubMed:16629901}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR008376 Synembryn
IPR016024 Armadillo-type fold
IPR019318 Guanine nucleotide exchange factor, Ric8
PFAM PF10165
PRINTS PR01802
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPQ8
PhosphoSite PhosphoSite-Q9NPQ8
TrEMBL E9PMP0
UniProt Splice Variant
Entrez Gene 60626
UniGene Hs.592292
RefSeq NP_001273063
HUGO HGNC:29550
OMIM 609146
CCDS CCDS65982
HPRD 12373
IMGT
EMBL AC069287 AK022870 AK027090 AK027461 AL136935 AL390088 BC011821 BC111499 BC121807 BC121808 BX538115
GenPept AAH11821 AAI11500 AAI21808 AAI21809 BAB14282 BAB15653 BAB55126 CAB66869 CAB98211 CAD98025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca