Version 5.4
Homo sapiens Protein: NUSAP1
Summary
InnateDB Protein IDBP-588416.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUSAP1
Protein Name nucleolar and spindle associated protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000454097
InnateDB Gene IDBG-7026 (NUSAP1)
Protein Structure
UniProt Annotation
Function Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269PubMed:12963707}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome {ECO:0000250}. Note=Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis. {ECO:0000250, ECO:0000269PubMed:17276916, ECO:0000269PubMed:17618083}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000281 mitotic cytokinesis
GO:0007076 mitotic chromosome condensation
GO:0040001 establishment of mitotic spindle localization
GO:0045840 positive regulation of mitosis
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXS6
PhosphoSite PhosphoSite-Q9BXS6
TrEMBL
UniProt Splice Variant
Entrez Gene 51203
UniGene Hs.615092
RefSeq NP_001230071
HUGO HGNC:18538
OMIM 612818
CCDS CCDS58356
HPRD
IMGT
EMBL AC087721 AF090915 AF217513 AF290612 AF305711 AK023483 AK222819 AK293168 AL833611 BC001308 BC010838 BC012887 BC024772 CH471125
GenPept AAF24034 AAF67624 AAG25874 AAH01308 AAH10838 AAH12887 AAH24772 AAK28023 BAB14586 BAD96539 BAG56712 EAW92483 EAW92486

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca